Zvizoro Zvinochenesa uyePigmentKugadzira muviri
Kuumbwa kweMelanin mumasero kwakakamurwa kuita nguva dzakasiyana. Masayendisiti anotenda kuti zvinokwanisika kudzidza zvinhu zvinochenesa muviri uye kushanda panguva dzakasiyana dzemetabolism.
(1) Danho rekutanga rekugadzirwa kwemelanin
① Zvinokanganisa kunyorwa uye/kana glycosylation yetyrosinase; ② Zvinodzivisa zvinodzora pakuumbwa kwetyrosinase; ③ Kudzorwa kwetyrosinase mushure mekunyora.
(2) Nguva yekugadzira Melanin
Senzira huru ye enzyme uye enzyme inoderedza mwero we melanin, tyrosinase inhibitors ndiyo nzira huru yekutsvaga nekusimudzira parizvino. Sezvo mishonga yakawanda yekuchenesa yakaita se phenol ne catechol derivatives yakafanana nemaumbirwo e tyrosine ne dopa, mishonga yekuchenesa yakaongororwa inowanzo rongwa semishonga isingakwikwidzane kana yekukwikwidzana ye tyrosinase.
(3) Danho rekupedzisira rekugadzirwa kwemelanin
①Inodzivirira kutapurirana kwe melanosome; zvinhu zvine serine protease inhibitory effect, zvakaita se rwj-50353, zvinodzivirira zvachose UBV-induced epidermal pigmentation; soybean trypsin inhibitor ine pachena mhedzisiro yekuchena asi haina mhedzisiro pahupfu hwemasero e pigment; Niacinamide, inogona kukanganisa kutapurirana kwe melanocytes pakati pe melanocytes ne keratinocytes; ② Melanin dispersion and metabolism, α-hydroxy acid, free fatty acid uye retinoic acid, zvinokurudzira kuvandudzwa kwemasero uye zvinokurudzira melaninized keratinocytes kubviswa.
Zvakakosha kuziva kuti tsvakiridzo nekushandiswa kwezvinhu zvinochenesa zvichibva pakushandiswa kwe melanin pamusoro apa hazvina kukodzera kudzivirira nekurapa ma plaque eganda. Sezvo mashandiro ekuumbwa kwe plaque yeganda ane chekuita nekuumbwa kwe lipofuscin, zvinhu zvinorwisa oxidative active zvinowanzo shandiswa kunonotsa uye kudzosera kumashure ma plaque eganda ane ruvara.
Nguva yekutumira: Chikunguru-29-2022
