Zvinhu Zvitatu Zvekuchembera Ganda

Nhamba yekutanga yekukwegura kweganda:

UV mwaranzi, kutora mifananidzo

70% yekuchembera kweganda kunobva kufotoaging

Mwaranzi yeUV inokanganisa collagen mumuviri wedu, inoita kuti ganda rirambe richitaridzika diki. Kana collagen ichiderera, ganda rinenge radzikira elasticity, sagging, dullness, kusaenzana kweganda tone, hyperpigmentation, pigmentation uye mamwe matambudziko eganda.

Kupenya kwezuva kwakakamurwa kuita UVA neUVB. Mwaranzi yeUVB ine marefu marefu uye inogona kungopisa chikamu chepamusoro cheganda redu, isingakwanise kupinda mukati meganda; zvisinei, mwaranzi yeUVA ine marefu marefu uye inogona kupinda mukati megirazi uye yakadzika mukati meganda, pakupedzisira ichinetesa iyo collagen uye ichitungamira mukukura kwemakwinya.

Mumashoko akareruka, UVA inotungamira mukuchembera, UVB inotungamira mukupisa, uye mwenje weultraviolet unogona kukuvadza cellular DNA, kuderedza fibroblast chiitiko, uye collagen synthesis yakavharwa, zvichitungamira kukuchinja kwesero, kuchembera, uye apoptosis. Saka, UV iri kwese kwese, kungave kwezuva kana kuine makore, unofanirwa kuita basa rakanaka rekudzivirira zuva.

Chechipiri chinonyanya kukosha pakukwegura kweganda

Oxidative yemahara radicals

Izwi rakakosha remahara radicals i'oxygen'. Tinofema inenge 98 kusvika 99 muzana yeokisijeni nguva dzose patinofema; inoshandiswa kupisa chikafu chatinodya uye kuburitsa mamorekuru madiki kuti masero edu aite metabolism, uye inoburitsa simba rakawanda kuita kuti tsandanyama dzedu dzishande.

Asi zvichida 1% kana 2% yeokisijeni inosarudza nzira yakasiyana uye ine ngozi, iyi shoma shoma yeokisijeni, inowanzonzi mahara radicals, iyo inorwisa masero edu. Nokufamba kwenguva, kukanganisa uku kunowedzera nekufamba kwenguva.

Chinonyanya kuoneka zviratidzo zvekukwegura zvinoratidzira paganda. Muviri wedu une nzira yekudzivirira inogadzirisa kukuvadzwa kunoitwa kumasero edu nemahara radicals, asi kana mahara radicals akaungana nekukurumidza kupfuura masero emuviri anogona kuagadzirisa, ganda rinokura zvishoma nezvishoma.

Mufananidzo uri pamusoro apa ndiwo chaiwo weganda remuviri wedu, unogona kuona zvakajeka kuti epidermis yepamusoro yakasviba uye dermis yepasi inopenya zvishoma, dermis ndipo patinogadzira collagen, uye masero anogadzira collagen anonzi fibroblasts, collagen kugadzira michina.

Iyo fibroblasts iri pakati pemufananidzo ndiyo fibroblasts, uye dandemutande rakavapoteredza i collagen. Collagen inogadzirwa nefibroblasts, uye ganda rechidiki rine mativi matatu uye rakarukwa zvakasimba collagen network, ine fibroblasts inodhonza zvine simba pama collagen fibers kupa ganda rechidiki kuzara uye kutsetseka kwemavara.

Uye ganda rekare, fibroblasts uye collagen link pakati pekuparara kwefibroblasts yakwegura inowanzoramba kupinda kwe collagen, nekufamba kwenguva, ganda rakatangawo kukwegura, izvi ndizvo zvatinowanzoti kukwegura kweganda, tinogadzirisa sei oxidation ye ganda rakagamuchirwa?

Mukuwedzera pakubhadhara zvakanyanya kune sunscreen, tinogona kushandisa zvimwe zvine vhitamini A, vitamin E, ferulic acid, resveratrol uye zvimwe zvinoshandiswa zveganda rekuchengetedza zvigadzirwa; kazhinji inogonawo kudya michero nemiriwo ine mavara akajeka, sematomatisi, madomasi ane lycopene yakawanda.

Inogona kutora okisijeni zvakanaka uye kudzivirira oxidative kusagadzikana, iwe unogonawo kudya yakawanda broccoli, broccoli ine chikamu chinonzi mustard mafuta glycosides, mushure mekudya kwechinhu ichi, ivo vachachengetwa muganda, kuitira kuti masero eganda anogona kuzvidzivirira. , michero iyi nemiriwo zvinogona kukurudzira kurwisa kwesero kukwegura.

Chechitatu chinonyanya kukosha pakukwegura kweganda

Ganda glycation

Glycation, mumashoko ehunyanzvi, inonzi isiri-enzymatic glycosylation reaction kana Melad reaction. Nheyo ndeyokuti kuderedza shuga kunosunga mapuroteni mukusavapo kwema enzymes; kuderedza shuga kunogadziriswa zvakanyanya nemapuroteni, uye kuderedza shuga uye mapuroteni kunopinda kwenguva yakareba oxidation, dehydrogenation, uye rearrangement reaction, zvichiita kuti pave nekugadzirwa kwekupedzisira-danho rekupedzisira glycosylation end-products, kana AGEs kwenguva pfupi.

AGE iboka rekusagadziriswa, yero-brownish, yakabatana nemararamiro emararamiro asingatyi kuparadzwa kwe enzyme, uye ndeimwe yezvikonzero zvikuru zvekukwegura kwevanhu. Sezvo isu takura, AGEs inounganidza mumuviri, zvichiita kuti kuwedzere kuoma kwemukati masvingo emidziyo yeropa, kusaenzana kwefupa metabolism inotungamirira ku osteoporosis, uye kuparadzwa kwe collagen uye elastin fibers mudermis inotungamirira kukwegura kweganda. Kuchembera kweganda kunokonzerwa neglycation inopfupikiswa mumutsara mumwechete: shuga inoparadza mapuroteni ane hutano uye inoshandura mapuroteni madiki maumbirwo ekare mapuroteni maumbirwo, zvichiita kuti kuchembera uye kurasikirwa kwe elasticity ye collagen uye elastic fibers mudermis.