Novel tekinoroji yekurapa rosacea uchishandisa yakanyanya pulse tekinoroji: In vivo uye zvidzidzo zvekiriniki

Background:Rosacea chirwere chisingaperi chinopisa cheganda chinokanganisa kumeso, uye iko zvino kurapwa maitiro haagutsi. Zvichienderana nephotomodulation yeoptimal pulse tekinoroji (OPT), takagadzira nzira yekurapa nyowani, inova, advanced OPT ine simba rakaderera, matatu pulse, uye refu pulse wide (AOPT-LTL).

Zvinangwa:Isu takavavarira kuongorora kugona uye ari pasi pemamorekuru maitiro eAOPT-LTL kurapwa mune rosacea-senge mbeva modhi. Uyezve, takaongorora kuchengetedzwa uye kushanda kwevarwere vane erythematotelangiectatic rosacea (ETR).

Zvishandiso uye nzira:Morphological, histological, uye immunohistochemical analyzes yakashandiswa kuongorora kushanda uye nzira dzeAOPT-LTL kurapwa muLL-37-induced rosacea-like mouse model. Uyezve, varwere ve23 vane ETR vakabatanidzwa uye vakagamuchira nguva dzakasiyana dzekurapa panguva dzemavhiki e2 zvichienderana nekuoma kwemamiriro avo. Mhedzisiro yekurapa yakaongororwa nekuenzanisa mapikicha ekiriniki panguva yekutanga, 1 vhiki, uye 3 mwedzi mushure mekurapa, yakasanganiswa nehuwandu hutsvuku, GFSS, uye CEA scores.

Mhinduro:Mushure mekurapa kweAOPT-LTL yemakonzo, takaona kuti rosacea-like phenotype, inflammatory cell infiltration, uye vascular abnormalities zvakagadziridzwa zvakanyanya, uye kutaura kweiyo core molecules ye rosacea yakadziviswa zvakanyanya. Muchidzidzo chekiriniki, kurapwa kweAOPT-LTL kwakaratidza kurapa kunogutsa pa erythema uye kuyerera kwevarwere veETR. Hapana zviitiko zvakakomba zvakashata zvakaonekwa.

Mhedziso:AOPT-LTL inzira yakachengeteka uye inoshanda yekurapa kweETR.